with low risk phytosanitary PPP registration

for control of powdery mildew

Active substance


FytoSave® is a new elicitor of the natural defenses of plants against powdery mildew-type diseases. The product is born as a result of the research of the spin-off Fytofend of the University of Namur (Belgium), in collaboration with LIDA Plant Research.

The active substance is a patented complex of oligosaccharides of natural origin that come, on the one hand, from chitin (chito-oligosaccharides or “COS”) and on the other, from pectin (oligogalacturonides or “OGA”) thus forming the COS complex -OGA.

This complex has been approved and included in Europe within the list of active substances according to Regulation CE 1107/2009 for the commercialization of phytosanitary products, within the category of low-risk phytosanitary without residues for the control of powdery mildew.

FytoSave® is registered in Spain as a low risk phytosanitary under Mutual Recognition with the authorization number ES-00209.

Fytosave Fitovacuna con registro fitosanitario para control del oídio

How it works


Plant  membrane receptors recognize the COS-OGA elicitor, transmitting a biochemical signal that triggers a cascade of natural defense reactions activating innate immunity:

  Activation of the genes responsible for strengthening the cell wall that allows limiting and confining the pathogen. This mechanical effect can occur due to a deposition of callose and / or phenolic compounds such as lignin and suberin produced by the phenylpropanoid pathway.

  Production of low molecular weight phytoalexins with great antimicrobial activity.

  Synthesis of defense proteins that accumulate in vacuoles and intercellular spaces colonized by the pathogen, among which are chitinases and glucanases, enzymes produced by plants whose catalytic activity is directed at the components of the pathogen’s cell wall .

Transcriptomic study


Transcriptomic study using q-PCR technology (quantitative Polymerase Chain Reaction) where the expression of defense genes PR1, PR2, PR3 related to Systemic Acquired Resistance (SAR) and where the genes associated with Induced Systemic Resistance (ISR) belonging to the Jasmonic Acid (JA) and Ethylene (ET) pathways are not expressed. SAR is regulated by the Salicylic Acid (SA) route and is known for its protection against biotrophic pathogens such as Powdery Mildew.

imagen fytovacunas lida plant

Proteomic study


The proteomic study shows that when the active substance COS-OGA is applied on the leaves, 90% of the regulated proteins are overexpressed, being related to the following functions:

Advantages and benefits


   Minimizes and delays the appearance and virulence of Powdery Mildew.

  Biostimulating effect increasing vigor and final quality of the crop

  Perfect tool for Integrated Pest Management

  It allows to reduce the use of chemical phytosanitary product

  Leaves no residue, no security period, authorized for organic farming

  100% compatible with auxiliary insects and pollinators

  Does not generate resistance

  Resistant to washing, rain and ultraviolet radiation.

pimientos stemicol

Dose in vegetables


Greenhouse crops: Tomato, pepper, eggplant, zucchini, pumpkin, cucumber and melon

Dose in foliar application between 2 and 2.5 liters / ha

 for volumes less than 500 liters / ha,  doses of 2 liters / ha

 for volumes greater than 500 liters / ha,  doses of 2.5 liters / ha

Application time: Make at least 2 preventive applications 7 days apart to achieve maximum defense activity in the plant. Allows alternation and mixing with other anti-powdery mildew.

Maximum number of applications per cycle and crop: 5 applications.

Interval between applications: 7-10 days

Recommendations: Shake the container slightly before use. Ensure good wetting especially on the underside of the leaves.

Dose in grapes 


Vine and table grape

 for volumes less than 500 liters / ha, apply 2 liters / ha

 for volumes over 500 liters / ha, apply 2.5 liters / ha

Timing of application: Carry out at least 2 preventive applications 10-12 days apart to achieve maximum defense activity on the plant, starting the first application from the third true leaf.

It allows the alternation and mixtures with other antioidium and antimildius.

Maximum number of applications per cycle: 8 applications.

Interval between applications: 10-12 days

Recommendations: Shake the container slightly before use. Ensure good wetting especially on the underside of the leaves.

uva negra fytosave lida